Apathy is Associated With Lower Inferior Temporal Cortical Thickness in Mild Cognitive Impairment and Normal Elderly Individuals
Year: 2014
Type: article
Study design: Observational Study
Abstract: Apathy is a common neuropsychiatric symptom in Alzheimer's disease dementia and amnestic mild cognitive impairment and is associated with cortical atrophy in Alzheimer's disease dementia. This study investigated possible correlations between apathy and cortical atrophy in 47 individuals with mild cognitive impairment and 19 clinically normal elderly. Backward elimination multivariate linear regression was used to evaluate the cross-sectional relationship between scores on the Apathy Evaluation Scale and thickness of several cortical regions and covariates. Lower inferior temporal cortical thickness was predictive of greater apathy. Greater anterior cingulate cortical thickness was also predictive of greater apathy, suggesting an underlying reactive process.
Source: Journal of Neuropsychiatry
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Mentoring Imaging Research in Early AD, G5345118568, G611802359, Evolution of memory related fMRI activation over the course of MCI and AD, Characterizing the Evolution of Amyloid Deposition in Normal Elderly, G670286326, G7782392434, Massachusetts Alzheimer's Disease Research Center (MADRC)
OpenAlex ID: W2099148018