Work

Insertion and truncation of c-myb by murine leukemia virus in a myeloid cell line derived from cultures of normal hematopoietic cells

Year: 1987

Type: article

Abstract: A retroviral insertion into the c-myb gene, which resulted in a 3' truncation, was found in an in vitro-derived myeloid cell line. The retroviral insertion occurred at precisely the same nucleotide at which another murine leukemia virus insertion occurred in an in vivo-induced myeloid leukemia. These findings suggest that comparable events may be required for the derivation of myeloid cell lines in vitro and for induction of myeloid leukemia in vivo.

Source: Journal of Virology

DOI: 10.1128/jvi.61.7.2339-2343.1987

Authors: Y Weinstein, J L Cleveland, D S Askew, U R Rapp, J N Ihle

Language: English

Topic: T-cell and Retrovirus Studies

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: U.S. Public Health Service, National Cancer Institute

Awards: G398599575, Moffitt Cancer Center Support Grant