Etiology of Iop Elevation in Primary Open Angle Glaucoma.
Year: 2009
Type: article
Abstract: Ask any clinician or basic scientist who has studied aqueous outflow for many years “What is the etiology of IOP elevation in POAG?” Each will have their pet theory but each will also tell you that we do not know. This review is thus a summary of existing clues rather than a direct answer to the question, “Where does aqueous outflow resistance reside and how is it generated?” We simply do not know. Equally important, we do not know whether the added resistance that elevates intraocular pressure (IOP) in primary open angle glaucoma (POAG) is due to more resistance in the same location as that in which the resistance of the normal eye is found, or an additional resistance that is added downstream in the glaucomatous eye.
In this regard it is important to recall the corollary to Kirchhoff’s law that resistances placed in series are additive.
Only recently has evidence arisen that the added resistance of the POAG eye might lie, at least in part, in a location other than that which appears to harbor most of the resistance in the normal eye. In this review, we will consider some of the principal theories of outflow resistance, concluding with recent data implicating an added resistance in a previously unappreciated location.
Source: PubMed
Authors: Thomas F Freddo, Haiyan Gong
Institution: University of Waterloo
Language: English
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funder: National Eye Institute
OpenAlex ID: W209937305