Work

Realtime photoacoustic microscopy in vivo with a 30-MHz ultrasound array transducer

Year: 2008

Type: article

Abstract: We present a novel high-frequency photoacoustic microscopy system capable of imaging the microvasculature of living subjects in realtime to depths of a few mm. The system consists of a high-repetition-rate Q-switched pump laser, a tunable dye laser, a 30-MHz linear ultrasound array transducer, a multichannel high-frequency data acquisition system, and a shared-RAM multi-core-processor computer. Data acquisition, beamforming, scan conversion, and display are implemented in realtime at 50 frames per second. Clearly resolvable images of 6-microm-diameter carbon fibers are experimentally demonstrated at 80 microm separation distances. Realtime imaging performance is demonstrated on phantoms and in vivo with absorbing structures identified to depths of 2.5-3 mm. This work represents the first high-frequency realtime photoacoustic imaging system to our knowledge.

Source: Optics Express

DOI: 10.1364/oe.16.007915

Authors: Roger J. Zemp, Liang Song, Rachel Bitton, K. Kirk Shung, Lihong V. Wang

Institutions: Washington University in St. Louis, University of Southern California

Language: English

Topic: Photoacoustic and Ultrasonic Imaging

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $2,270

Funders: National Institutes of Health, National Institute of Neurological Disorders and Stroke, National Institute of Biomedical Imaging and Bioengineering