Work

A Morphological and Immunohistochemical Comparison of Mammary Tissues from the Short-Tailed Fruit Bat (Carollia perspicillata) and the Mouse1

Year: 2004

Type: article

Abstract: In the present study, mammary tissues from the fruit bat (Carollia perspicillata) and mouse (Mus musculus) were compared using histological and immunohistochemical methods. Because the female bat exhibits greater reproductive similarities to humans, it might provide a useful animal model for studying mammary physiology and disease with relevance to our own species. In lactating and recently lactating specimens, bat tissue had significantly fewer adipocytes and more collagenous connective tissue compared to the mouse. The proteins Stat5a, keratin 5, Npt2b, and E-cadherin were all similarly localized in mouse and bat mammary tissues taken from lactating animals. The present study demonstrates that whereas the epithelial compartment and the presence of differentiation markers are conserved between the mouse and bat, differences exist in the stromal compartment.

Source: Biology of Reproduction

DOI: 10.1095/biolreprod.103.022988

Authors: Jennifer L. Evarts, John J. Rasweiler, Richard R. Behringer, Lothar Hennighausen, Gertraud W. Robinson

Institutions: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, State University of New York, SUNY Downstate Health Sciences University, The University of Texas MD Anderson Cancer Center

Language: English

Topic: Comparative Animal Anatomy Studies

Subfield: Urology

Field: Medicine

Domain: Health Sciences

Open Access status: bronze

Funder: National Science Foundation

Award: Comparative Genetic Studies of Limb Development in Bats and Mice