Work

Direct α‐Arylation of Ethers through the Combination of Photoredox‐Mediated CH Functionalization and the Minisci Reaction

Year: 2014

Type: article

Abstract: The direct α-arylation of cyclic and acyclic ethers with heteroarenes has been accomplished through the design of a photoredox-mediated CH functionalization pathway. Transiently generated α-oxyalkyl radicals, produced from a variety of widely available ethers through hydrogen atom transfer (HAT), were coupled with a range of electron-deficient heteroarenes in a Minisci-type mechanism. This mild, visible-light-driven protocol allows direct access to medicinal pharmacophores of broad utility using feedstock substrates and a commercial photocatalyst.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201410432

Authors: Jian Jin, David W. C. MacMillan

Institution: Princeton University

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funder: National Institute of General Medical Sciences

Award: Combining Nickel and Photoredox Catalysis