Work

Post-market in vitro bioequivalence study of six brands of ciprofloxacin tablets/caplets in Jos, Nigeria

Year: 2009

Type: article

Abstract: Six brands of ciprofloxacin 500 mg tablets have been evaluated using some quality control tests of uniformity of weight, hardness, friability, assay, disintegration and dissolution with the aim to assess its bioequivalence. The results obtained have been discussed in some details using monographs in the two Pharmacopeia (United States Pharmacopeia, USP and British Pharmacopeia, BP). The results were also subjected to statistical analysis. In particular, the dissolution test results were subjected to further tests to determine significance of ANOVA, significance of Dunnett’s test, dissolution efficiency, difference factor (f1) and similarity factor (f2). Subsequently the results indicated that 3 of the 6 (50%) brands may not be used interchangeably with the chosen ‘innovator’ brand.

Source: Scientific Research and Essays

DOI: 10.5897/sre.9000747

Authors: Ndidi C. Ngwuluka, K. Lawal, Patrick O. Olorunfemi, Nelson A. Ochekpe

Language: English

Topic: Pharmaceutical Quality and Counterfeiting

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W2099463988

FWCI: 1.992

Cites: 24

Cited by: 31

Related to: 10