Modulation of Synaptic Transmission by Metabotropic Glutamate Receptors and Endocannabinoid Signaling
Year: 2006
Type: dissertation
Abstract: Metabotropic glutamate receptors (mGluRs) are distributed throughout the central nervous \\nsystem and play important roles in the modulation of synaptic transmission. The mGluRs \\nregulate long-term potentiation (LTP)/long-term depression (LTD) and learning and memory \\nin hippocampus. This group of glutamate receptors are also reported to exert anticonvulsive \\nand neuroprotective efficacy, especially group I mGluRs. Kindling induced by repeated \\napplication of the convulsant pentylenetetrazole (PTZ) is a validated model of epilepsy and \\nepilepsy-related neuromorphological, neurophysiological and behavioural alterations. In this \\nthesis, the role of group I metabotropic glutamate receptors (mGluRs) in PTZ induced \\nseizures, kindling, kindling-related learning deficits and LTP were examined.
Author: Raghavendra Y. Nagaraja
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2099549316