Work

Endocrine fibroblast growth factors 15/19 and 21: from feast to famine

Year: 2012

Type: preprint

Abstract: We review the physiology and pharmacology of two atypical fibroblast growth factors (FGFs)-FGF15/19 and FGF21-that can function as hormones. Both FGF15/19 and FGF21 act on multiple tissues to coordinate carbohydrate and lipid metabolism in response to nutritional status. Whereas FGF15/19 is secreted from the small intestine in response to feeding and has insulin-like actions, FGF21 is secreted from the liver in response to extended fasting and has glucagon-like effects. FGF21 also acts in an autocrine fashion in several tissues, including adipose. The pharmacological actions of FGF15/19 and FGF21 make them attractive drug candidates for treating metabolic disease.

Source: Genes & Development

DOI: 10.1101/gad.184788.111

Authors: Matthew J. Potthoff, Steven A. Kliewer, David J. Mangelsdorf

Institutions: Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center

Language: English

Topic: Fibroblast Growth Factor Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze