Work

Crystal structure ofN-{N-[N-acetyl-(S)-leucyl]-(S)-leucyl}norleucinal (ALLN), an inhibitor of proteasome

Year: 2015

Type: article

Abstract: The title compound, C20H37N3O4, also known by the acronym ALLN, is a tripeptidic inhibitor of the proteolytic activity of the proteasomes, enzyme complexes implicated in several neurodegenerative diseases and other disorders, including cancer. The crystal structure of ALLN, solved from synchrotron radiation diffraction data, revealed the mol-ecules in extended conformation of the backbone and engaging all peptide N and O atoms in inter-molecular hydrogen bonds forming an infinite anti-parallel β-sheet.

Source: Acta Crystallographica Section E Crystallographic Communications

DOI: 10.1107/s2056989015002091

Authors: Andrzej Czerwinski, Channa Basava, Miroslawa Dauter, Zbigniew Dauter

Institutions: Peptides International (United States), Argonne National Laboratory, Leidos Biomedical Research Inc. (United States), National Cancer Institute

Language: English

Topic: Crystal structures of chemical compounds

Subfield: Inorganic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $500