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Nanoscopy in a Living Mouse Brain

Year: 2012

Type: article

Abstract: We demonstrated superresolution optical microscopy in a living higher animal. Stimulated emission depletion (STED) fluorescence nanoscopy reveals neurons in the cerebral cortex of a mouse with <70-nanometer resolution. Dendritic spines and their subtle changes can be observed at their relevant scales over extended periods of time.

Source: Science

DOI: 10.1126/science.1215369

Authors: Sebastian Berning, Katrin I. Willig, Heinz Steffens, Payam Dibaj, Stefan W. Hell

Institutions: Max Planck Institute for Biophysical Chemistry, Max Planck Institute of Experimental Medicine

Language: English

Topic: Advanced Fluorescence Microscopy Techniques

Subfield: Biophysics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W2099714571

FWCI: 19.72

Cites: 7

Cited by: 380

Related to: 10