Year: 1996
Type: article
Abstract: nergy is a cellular state in which a lymphocyte is ahve but fails to display certain functional responses when optimally stimulated through both its antigen-specific receptor and any other receptors that are normally required for full activation. The term was initially used by Nossal and Pike (1) to describe an unresponsive state induced by the injection of soluble protein antigens in vivo, in which the antigen-specific B cells were still found to be present in the animal, but these cells could not be reactivated by antigen or mitogen to make Ig. The first observation of proliferative unresponsiveness induced in purified T cells using peptide antigens was made on human CD4 + clones (2). The results were initially interpreted as a direct inactivation of the T cells through recognition of free antigen; however, subsequent blocking studies with anti-Ia antibodies revealed
DOI: 10.1084/jem.184.1.1
Author: R H Schwartz
Institution: National Institutes of Health
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2099748840