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Cellular Response to Ionizing Radiation: A MicroRNA Story.

Year: 2012

Type: article

Abstract: MicroRNAs (miRNAs) represent a class of small non-coding RNA molecules that regulate gene expression at the post-transcriptional level. They play a crucial role in diverse cellular pathways. Ionizing radiation (IR) is one of the most important treatment protocols for patients that suffer from cancer and affects directly or indirectly cellular integration. Recently it has been discovered that microRNA-mediated gene regulation interferes with radio-related pathways in ionizing radiation. Here, we review the recent discoveries about miRNAs in cellular response to IR. Thoroughly understanding the mechanism of miRNAs in radiation response, it will be possible to design new strategies for improving radiotherapy efficiency and ultimately cancer treatment.

Source: Europe PMC (PubMed Central)

Authors: Mohammad Halimi, S Mohsen Asghari, Reyhaneh Sariri, Dariush Moslemi, Hadi Parsian

Institutions: University of Guilan, Babol University of Medical Sciences

Language: English

Topic: MicroRNA in disease regulation

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2099766501

FWCI: 0.609

Cites: 54

Cited by: 29

Related to: 10