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Organocatalytic Asymmetric Alkylation of Aldehydes by SN1‐Type Reaction of Alcohols

Year: 2009

Type: article

Abstract: Work-alcoholic! The elusive enantioselective catalytic alpha-alkylation of aldehydes, a widely sought transformation, was brought to execution by the use of alcohols capable of forming stabilized carbocations (see scheme, TFA = trifluoroacetic acid).

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.200805423

Authors: Pier Giorgio Cozzi, Fides Benfatti, Luca Zoli

Institution: University of Bologna

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

OpenAlex ID: W2099798519

FWCI: 15.25

Cites: 79

Cited by: 260

Related to: 10