Work

Health and function of participants in the Long Life Family Study: A comparison with other cohorts

Year: 2011

Type: article

Study design: Observational Study

Abstract: Individuals from families recruited for the Long Life Family Study (LLFS) (n= 4559) were examined and compared to individuals from other cohorts to determine whether the recruitment targeting longevity resulted in a cohort of individuals with better health and function. Other cohorts with similar data included the Cardiovascular Health Study, the Framingham Heart Study, and the New England Centenarian Study. Diabetes, chronic pulmonary disease and peripheral artery disease tended to be less common in LLFS probands and offspring compared to similar aged persons in the other cohorts. Pulse pressure and triglycerides were lower, high density lipids were higher, and a perceptual speed task and gait speed were better in LLFS. Age-specific comparisons showed differences that would be consistent with a higher peak, later onset of decline or slower rate of change across age in LLFS participants. These findings suggest several priority phenotypes for inclusion in future genetic analysis to identify loci contributing to exceptional survival.

Source: Aging

DOI: 10.18632/aging.100242

Authors: Anne B. Newman, Nancy W. Glynn, Christopher A. Taylor, Paola Sebastiani, Thomas T. Perls, Richard Mayeux, Kaare Christensen, Joseph M. Zmuda, Sandra Barral, Joseph H. Lee, Eleanor M. Simonsick, Jeremy D. Walston, Anatoli I. Yashin, Evan Hadley

Institutions: University of Pittsburgh, Boston University, Boston Medical Center, Columbia University, University of Southern Denmark, National Institutes of Health, National Institute on Aging, Johns Hopkins University, Johns Hopkins Bayview Medical Center, Duke University

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: University of Pittsburgh, National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Neurological Disorders and Stroke, National Center for Advancing Translational Sciences

Awards: G1002540797, G109016790, G1177103769, G1220223050, G1224608327, CORONARY HEART DISEASE AND STROKE, CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84, G1401438683, G1412333385, CHS-ULTRASOUND READING, CORONARY HEART DISEASE AND STROKE, MRI READING CENTER FOR THE CARDIOVASCULAR HEALTH STUDY, CORONARY HEART DISEASE AND STROKE IN PEOPLE AGED 65-84, G1890355377, G1909643007, G2194386449, CORONARY HEART DISEASE AND STROKE IN PEOPLE AGED 65-84, CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84, G236442059, G2391884931, G247538147, Exceptional Survival: Trajectories to Functional Aging (CHS All Stars), CORONARY HEART DISEASE &STROKE IN THE ELDERLY, G274585943, G277826483, G2786044735, G2800149121, G2847759872, G2882309788, G2922038998, G3045517347, G3137375862, G3145043064, G3152630099, G3169706684, G328935669, G333228317, G3370719899, G337426736, G3560915123, CENTRAL BLOOD ANALYSIS LABORATORY FOR CHS, Predictors of Alheimers Disease in Mild Cognitive Impairment, G4012114008, G4048755144, Long Life Family Study: Duke Univ./Univ. of Southern Denmark Field Center, G423252844, G4365909528, G4380859766, G4454824495, Subcortical Hyperintensities in Sleep Apnea Syndrome, G4617276643, G4660668308, G4841521052, G4987078009, G5167412771, G573134505, G581887176, CHS Events Follow-up Study, G61834786, G6226795708, G640327682, Long Life Family Study: University of Pittsburgh Field Center, Long Life Family Study: Data Management and Coordinating Center, CHS-Transition Phase, G6832344490, G687544517, G6923371013, G693548699, G7035200923, G7176672723, G7286144250, CHS RETINAL READING CENTER, G764651519, CARDIOVASCULAR HEALTH STUDY--ECHOCARDIOGRAPHY, G766700449, G766843672, G777822606, G7999488110, G806768229, G8402048158, G8593276544, G859984287, G884570035, Pittsburgh Older Americans Independence Center, G904224959, G905174590, G905887895, G960597250

OpenAlex ID: W2099800366

FWCI: 7.67

Cites: 36

Cited by: 196

Related to: 10