Factors Associated With Retention Among Non–Perinatally HIV-Infected Youth in the HIV Research Network
Year: 2014
Type: article
Study design: Observational Study
Abstract: BACKGROUND: The transmission of human immunodeficiency virus (HIV) among youth through high-risk behaviors continues to increase. Retention in Care is associated with positive clinical outcomes and a decrease in HIV transmission risk behaviors. We evaluated the clinical and demographic characteristics of non-perinatally HIV (nPHIV)-infected youth associated with retention 1 year after initiating care and in the 2 years thereafter. We also assessed the impact retention in year 1 had on retention in years 2 and 3. METHODS: This was a retrospective analysis of treatment-naive nPHIV-infected 12- to 24-year-old youth presenting for care in 16 US HIV clinical sites within the HIV Research Network between 2002 and 2008. Multivariate logistic regression identified factors associated with retention. RESULTS: Of 1160 nPHIV-infected youth, 44.6% were retained in care during the first year, and 22.4% were retained in all 3 years. Retention in the first year was associated with starting antiretroviral therapy in the first year (adjusted odds ratio [AOR], 3.47 [95% confidence interval (CI), 2.57-4.67]), Hispanic ethnicity (AOR, 1.66 [95% CI, 1.08-2.56]), men who have sex with men (AOR, 1.59 [95% CI, 1.07-2.36]), and receiving care at a pediatric site (AOR, 5.37 [95% CI, 3.20-9.01]). Retention in years 2 and 3 was associated with being retained 1 year after initiating care (AOR, 7.44 [95% CI, 5.11-10.83]). CONCLUSION: A high proportion of newly enrolled nPHIV-infected youth were not retained for 1 year, and only 1 in 4 were retained for 3 years. Patients who were Hispanic, were men who have sex with men, or were seen at pediatric clinics were more likely to be retained in care. Interventions that target those at risk of being lost to follow up are essential for this high-risk population.
DOI: 10.1093/jpids/piu102
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: U.S. Department of Health and Human Services, Children's Hospital of Philadelphia, Johns Hopkins University, Drexel University, National Institutes of Health, Health Resources and Services Administration, Agency for Healthcare Research and Quality, U.S. Public Health Service, Center for AIDS Research, University of Washington, University of California, San Diego, Center for AIDS Research, Johns Hopkins University, National Institute of Mental Health, National Institute of Allergy and Infectious Diseases
Awards: G1214792496, G2088370805, G2146752487, G2483435703, G2744122616, HAART Initiation in Behaviorally HIV-Infected Youth, G6327337476, G653582874, G7178514535, G7800296869, Reducing Readmissions and Improving Outcomes in HIV-Infected Patients, G9000016375, G9000121584, The Johns Hopkins Center for AIDS Research (JHU CFAR), Evaluating Patient Retention in HIV Care
OpenAlex ID: W2099803113