Effectof Synbiotic Gaz Consumption on Insulin Resistance, Inflammatory Factors and Oxidative Stress Parameters in Patients With Type 2 Diabetes
Year: 2013
Type: article
Study design: Clinical Trial
Abstract: Background: Increased insulin resistance, inflammatory factors and oxidative stress parameters are associated with the development of diabetes complications. This study was designed to determine the beneficial effects of synbiotic Gaz on insulin resistance, inflammatory factors and oxidative stress in patients with type 2 diabetes. Materials and Methods: This randomized crossover double-blind controlled clinical trial was performed on 62 diabetic patients aged 35-70 years. Subjects were randomly assigned to consume of either the synbiotic (n=62) or control Gaz (n=62) for 6 weeks. A 3-week washout period considered. The synbiotic Gaz was consisted of Lactobacillus sporogenes (1×10 7 CFU), 0.04 g inulin, and 0.05 g stevia as sweetener per 1 g. Control Gaz was the same substance without probiotic bacteria and prebiotic inulin. Patients received synbiotic and control Gaz in a 7 g package thrice a day. Fasting blood samples were taken at baseline and 6 weeks after intervention to measure insulin resistance, hsCRP and biomarkers of oxidative stress. Results: Consumption of synbiotic Gaz, compared with control, resulted in a significant decrease in serum insulin (p=0.02) and hs-CRP levels (p=0.008). Supplementation with synbiotic Gaz led also to a significant increase in plasma total glutathione (p<0.001) compared to control group. Conclusions: In conclusion, consumption of synbiotic Gaz for 6 weeks resulted in decreased levels of serum insulin, hs-CRP and increased levels of plasma total glutathione.
Language: English
Subfield: Food Science
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W2100063020