Work

Noise in solid-state nanopores

Year: 2008

Type: article

Abstract: We study ionic current fluctuations in solid-state nanopores over a wide frequency range and present a complete description of the noise characteristics. At low frequencies (f approximately < 100 Hz) we observe 1/f-type of noise. We analyze this low-frequency noise at different salt concentrations and find that the noise power remarkably scales linearly with the inverse number of charge carriers, in agreement with Hooge's relation. We find a Hooge parameter alpha = (1.1 +/- 0.1) x 10(-4). In the high-frequency regime (f approximately > 1 kHz), we can model the increase in current power spectral density with frequency through a calculation of the Johnson noise. Finally, we use these results to compute the signal-to-noise ratio for DNA translocation for different salt concentrations and nanopore diameters, yielding the parameters for optimal detection efficiency.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.0705349105

Authors: R. M. M. Smeets, U. F. Keyser, N. H. Dekker, C. Dekker

Institutions: Delft University of Technology, Leipzig University

Language: English

Topic: Nanopore and Nanochannel Transport Studies

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: green

Funders: Stichting voor Fundamenteel Onderzoek der Materie, Nederlandse Organisatie voor Wetenschappelijk Onderzoek

OpenAlex ID: W2100085677

FWCI: 8.134

Cites: 23

Cited by: 381

Related to: 10