Work

Targeting the PI3K/AKT Pathway for the Treatment of Prostate Cancer

Year: 2009

Type: review

Abstract: Despite recent advances in our understanding of the biological basis of prostate cancer, the management of the disease, especially in the castration-resistant phase, remains a significant challenge. Deregulation of the phosphatidylinositol 3-kinase pathway is increasingly implicated in prostate carcinogenesis. In this review, we detail the role of this pathway in the pathogenesis of prostate cancer and the rapidly evolving therapeutic implications of targeting it. In particular, we highlight the importance of the appropriate selection of agents and combinations, and the critical role of predictive and pharmocodynamic biomarkers.

Source: Clinical Cancer Research

DOI: 10.1158/1078-0432.ccr-08-0125

Authors: Debashis Sarker, Alison H.M. Reid, Timothy A. Yap, Johann S. de Bono

Institutions: Royal Marsden NHS Foundation Trust, Institute of Cancer Research, Cancer Research UK

Language: English

Topic: Prostate Cancer Treatment and Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze