Work

Asymmetric Bioreduction of Activated Alkenes Using Cloned 12‐Oxophytodienoate Reductase Isoenzymes OPR‐1 and OPR‐3 from Lycopersicon esculentum (Tomato): A Striking Change of Stereoselectivity

Year: 2007

Type: article

Abstract: Tomato source: 12-Oxophytodienoate reductase isoenzymes OPR1 and OPR3 from tomato possess a broad substrate spectrum for the asymmetric bioreduction of α,β-unsaturated enals, enones, dicarboxylic acids, and N-substituted maleimides (see scheme). Stereocomplementary behavior of both isoenzymes was observed in the reduction of a nitroalkene that led to the formation of opposite stereoisomers in high enantiomeric excess.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.200605168

Authors: Mélanie Hall, Clemens Stueckler, Wolfgang Kroutil, Peter Macheroux, Kurt Faber

Institutions: University of Graz, Graz University of Technology

Language: English

Topic: Enzyme Catalysis and Immobilization

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Zero hunger

Open Access status: bronze

OpenAlex ID: W2100289296

FWCI: 4.157

Cites: 56

Cited by: 169

Related to: 10