Work

Nucleic Acid–Gold Nanoparticle Conjugates as Mimics of microRNA

Year: 2011

Type: article

Abstract: Novel conjugates of gold nanoparticles functionalized with synthetic microRNAs can enter cells without the aid of cationic co-carriers and mimic the function of endogenous microRNAs. These conjugates can regulate multiple proteins through interactions with the 3′ untranslated region of the target messenger RNA and control cell behavior. The conjugates are promising new tools for studying microRNA function and are candidates for microRNA replacement therapies.

Source: Small

DOI: 10.1002/smll.201101018

Authors: Liangliang Hao, Pinal C. Patel, Ali H. Alhasan, David A. Giljohann, Chad A. Mirkin

Institutions: Northwestern University, International Institute for Nanotechnology

Language: English

Topic: RNA Interference and Gene Delivery

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute