Year: 2009
Type: article
Abstract: Retinal pigment epithelial (RPE) stem cells offer a theoretical treatment strategy for a wide va-riety of retinal disorders including age-related macular degeneration (AMD) and retinal dys-trophies. There are, however, a number of hur-dles that will have to be overcome before a con-sistently reliable and successful therapy can be offered to patients. These include expansion of sufficient numbers of suitably differentiated cells for transplantation, technical issues around insertion of the cells and removal of damaged tissue (such as abnormal Bruch’s membrane in AMD), immunological rejection of transplanted cells, and control of post-trans-plant cell differentiation.1-3 Thus, in the case of
Source: PubMed Central
Authors: Paul Hiscott, Carl M Sheridan
Institution: University of Liverpool
Language: English
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2100363673