Work

Blockage of Tropoelastin Secretion by Monensin Represses Tropoelastin Synthesis at a Pretranslational Level in Rat Smooth Muscle Cells

Year: 1985

Type: article

Abstract: The blockage of protein secretion in the R22 cultured rat aortic smooth muscle cell strain with monensin repressed tropoelastin gene expression at the mRNA level by ca. 50-fold as measured by biosynthetic pulse-labeling, in vitro translation, and hybridization with a tropoelastin genomic DNA probe. These results suggest that tropoelastin gene expression is autoregulated, and they represent the first reported effect of monensin on gene expression.

Source: Molecular and Cellular Biology

DOI: 10.1128/mcb.5.1.253

Authors: S M Frisch, J M Davidson, Z Werb

Institutions: University of California, San Francisco, University of Utah, University of California, Berkeley

Language: English

Topic: Cellular Mechanics and Interactions

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: U.S. Department of Energy, National Institutes of Health, National Institute of General Medical Sciences

Awards: G1398330795, G3734054993, G7857958987, G809128514