ADHD and DAT1: Further evidence of paternal over‐transmission of risk alleles and haplotype
Year: 2009
Type: article
Study design: Observational Study
Abstract: We [Hawi et al. (2005); Am J Hum Genet 77:958-965] reported paternal over-transmission of risk alleles in some ADHD-associated genes. This was particularly clear in the case of the DAT1 3'-UTR VNTR. In the current investigation, we analyzed three new sample comprising of 1,248 ADHD nuclear families to examine the allelic over-transmission of DAT1 in ADHD. The IMAGE sample, the largest of the three-replication samples, provides strong support for a parent of origin effect for allele 6 and the 10 repeat allele (intron 8 and 3'-UTR VNTR, respectively) of DAT1. In addition, a similar pattern of over-transmission of paternal risk haplotypes (constructed from the above alleles) was also observed. Some support is also derived from the two smaller samples although neither is independently significant. Although the mechanism driving the paternal over-transmission of the DAT risk alleles is not known, these finding provide further support for this phenomenon.
DOI: 10.1002/ajmg.b.30960
Institutions: Trinity College Dublin, University of St Andrews, Radboud University Nijmegen, Radboud University Medical Center, University of Göttingen, Donders Institute for Brain, Cognition and Behaviour, Herzog Hospital, Universitat de València, Ghent University, Vrije Universiteit Amsterdam, University of Southampton, University of Basel, University of Zurich, Aarhus University Hospital, North Denmark Region, SUNY Upstate Medical University
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2100442637