Work

Stimulant-like action of nicotine on striatal dopamine transporter in the brain of adults with attention deficit hyperactivity disorder

Year: 2002

Type: article

Abstract: Eleven adult patients with attention deficit hyperactivity disorder (ADHD) without medication, consuming 7-40 cigarettes per day, showed statistically significant lower values for striatal dopamine transporter (DAT) measured by [99mTc]TRODAT-1 SPECT compared to 11 non-smoking drug-naive patients with ADHD, matched for sex and age, despite higher ADHD scores for the smokers. Because stimulants have been shown to reduce primarily elevated DAT density in adults with ADHD, it can be suggested that nicotine acts in a similar way on striatal DAT as do stimulants.

Source: The International Journal of Neuropsychopharmacology

DOI: 10.1017/s1461145702002821

Authors: Klaus-Henning Krause, Stefan H. Dresel, Johanna Krause, Hank F. Kung, Klaus Tatsch, Manfred Ackenheil

Institutions: Ludwig-Maximilians-Universität München, Medprevent Ottobrunn, University of Pennsylvania

Language: English

Topic: Attention Deficit Hyperactivity Disorder

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2100715167