Work

Enhanced Post-Stationary-Phase Survival of a Clinical Thymidine-Dependent Small-Colony Variant of Staphylococcus aureus Results from Lack of a Functional Tricarboxylic Acid Cycle

Year: 2007

Type: article

Abstract: The mechanisms underlying the persistence of the Staphylococcus aureus small-colony variant (SCV) are not fully elucidated. In this study, clinical thymidine-dependent SCVs displayed altered expression of citB, clpC, and arcA genes, reduced acetate catabolization, and enhanced survival. These results implicate the importance of changes in tricarboxylic acid cycle and acetic acid metabolism in SCV survival and persistence.

Source: Journal of Bacteriology

DOI: 10.1128/jb.01444-06

Authors: Indranil Chatterjee, Mathias Herrmann, Richard A. Proctor, Georg Peters, Barbara C. Kahl

Institutions: Saarland University, University of Wisconsin–Madison, University Hospital Münster

Language: English

Topic: Antimicrobial Resistance in Staphylococcus

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Deutsche Forschungsgemeinschaft, National Institutes of Health, National Institute of Allergy and Infectious Diseases