Work

Structures of the double‐ring AAA ATPase Pex1–Pex6 involved in peroxisome biogenesis

Year: 2015

Type: review

Abstract: The Pex1 and Pex6 proteins are members of the AAA family of ATPases and are involved in peroxisome biogenesis. Recently, cryo-electron microscopy structures of the Pex1-Pex6 complex in different nucleotide states have been determined. This Structural Snapshot describes the structural features of the complex and their implications for its function, as well as questions that still await answers.

Source: FEBS Journal

DOI: 10.1111/febs.13569

Authors: Dongyan Tan, Neil B. Blok, Tom A. Rapoport, Thomas Walz

Institutions: Harvard University, Howard Hughes Medical Institute, Rockefeller University

Language: English

Topic: Cellular transport and secretion

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Howard Hughes Medical Institute, National Institutes of Health, National Institute of General Medical Sciences

Awards: G2344519342, Medical Scientist Training Program, G5341054486, G6321917404, Protein Transport Across Membranes