Porównanie wpływu na spadek masy ciała poszczególnych ekstraktów ziół z mieszaniną ekstraktów ziołowych wywierających prawdopodobny efekt synergistyczny
Year: 2008
Type: article
Abstract: INTRODUCTION. The aim of the present study was to elucidate whether an interaction between different herbal extracts (green tea, Coleus forskohlii , yerba maté, Betula alba ) can take place and whether their combination could be more effective in terms of reducing body weight gain than each of the extracts alone. MATERIAL AND METHODS. Sixty rats were treated with different herbal extracts for 12 weeks. Their body weight and food intake was measured weekly. RESULTS. The mixture of herbs leads to a significantly lower body weight increase and lower food intake. The effect of separate herbs was found to be relatively small, a significantly higher weight-increase inhibiting effect was found when using a mixture of herbal extracts. CONCLUSIONS. A synergic interaction between the components of a herbal mixture is suggested as a possible explanation for the above findings. The probable working mechanism can involve the different modes of action described for the components of the mixture of herb extracts. These mechanisms can involve a decrease in noradrenaline breakdown and an increase in thermogenesis, together with an antioxidative effect and suppressive effect on NFkB activity. The inhibition of adipocyte proliferation and an anorectic effect influencing food intake have also been described for the ingredients included in the mixture. It is suggested that the mixture of different plant extracts can exert several of these effects working in synergy.
Source: Via Medica Journals
Authors: M Krotkiewski, Radosław Janiak
Institution: University of Gothenburg
Language: Polish
Subfield: Pharmacology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2101180915