Work

Germ Cell Transport Across the Seminiferous Epithelium During Spermatogenesis

Year: 2014

Type: review

Abstract: Transport of germ cells across the seminiferous epithelium is crucial to spermatogenesis. Its disruption causes infertility. Signaling molecules, such as focal adhesion kinase, c-Yes, c-Src, and intercellular adhesion molecules 1 and 2, are involved in these events by regulating actin-based cytoskeleton via their action on actin-regulating proteins, endocytic vesicle-mediated protein trafficking, and adhesion protein complexes. We critically evaluate these findings and provide a hypothetical framework that regulates these events.

Source: Physiology

DOI: 10.1152/physiol.00001.2014

Authors: Xiang Xiao, Dolores D. Mruk, Chris K. C. Wong, C. Yan Cheng

Institutions: Population Council, Hong Kong Baptist University

Language: English

Topic: Sperm and Testicular Function

Subfield: Reproductive Medicine

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funder: Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: Biology of the Blood-Testis Barrier, Cooperative Contraceptive Research Center: New Contraceptives with Dual Benefits