Work

Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development

Year: 1998

Type: preprint

Abstract: The transcription factor SCL/tal-1 is essential for blood cell development. Though it is also expressed in vascular endothelium, SCL has been considered dispensable for vessel formation. Through transgenic rescue of hematopoietic defects of SCL-/- embryos and analysis of chimeras generated with SCL-/- ES cells tagged with a transgene expressed in vascular endothelial cells, we show that SCL is essential for angiogenic remodeling of the yolk sac capillary network into complex vitelline vessels. These findings establish a role for SCL in embryonic angiogenesis and argue for critical functions in both embryonic blood and vascular cells, the descendents of the presumptive hemangioblast.

Source: Genes & Development

DOI: 10.1101/gad.12.4.473

Authors: J. E. Visvader, Y. Fujiwara, S. H. Orkin

Institutions: Howard Hughes Medical Institute, Harvard University

Language: English

Topic: Angiogenesis and VEGF in Cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: Howard Hughes Medical Institute