Work

Targeting Histone Demethylases in Cancer Therapy

Year: 2009

Type: article

Abstract: A novel oligoamine analog inhibitor of histone demethylases blocks colon tumor cell growth in association with histone methylation and gene re-expression. It also markedly potentiates the activity of hypomethylating agents in vitro and in vivo, suggesting that histone demethylase inhibitors may represent a valuable addition to the armamentarium of epigenetic agents.

Source: Clinical Cancer Research

DOI: 10.1158/1078-0432.ccr-09-2399

Author: Steven Grant

Institutions: Virginia Commonwealth University, VCU Massey Comprehensive Cancer Center

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute