Work

Embryonic mouse submandibular salivary gland morphogenesis and the TNF/TNF-R1 signal transduction pathway

Year: 2001

Type: article

Abstract: TNF is a pleiotropic cytokine that modulates cell proliferation and apoptosis. The objective of the present study was to investigate the possible function(s) of the TNF/TNF-R1 signaling pathway in embryonic mouse submandibular salivary gland (SMG) morphogenesis. After characterizing in vivo mRNA and protein expression of various constituents of this pathway, we utilized in vitro experiments to investigate the phenotypic outcomes of enhanced and deficient ligand. The results of these experiments indicate that the TNF/TNF-R1 signal transduction pathway plays an important role in balancing cell proliferation and apoptosis during SMG duct and presumptive acini formation.

Source: The Anatomical Record

DOI: 10.1002/1097-0185(20010301)262:3<318::aid-ar1023>3.0.co;2-3

Authors: Michael Melnick, Haiming Chen, Yanmin Zhou, Tina Jaskoll

Institution: University of Southern California

Language: English

Topic: Salivary Gland Disorders and Functions

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Celgene, National Institutes of Health, National Institute of Dental and Craniofacial Research