Work

Evidence for a Quasi-Equilibrium Distribution of States for Bradykinin [M + 3H]3+ Ions in the Gas Phase

Year: 2010

Type: article

Abstract: Multidimensional ion mobility spectrometry coupled with mass spectrometry (IMS-IMS-MS) techniques are used to select and activate six different gas-phase conformations of bradykinin [M + 3H](3+) ions. Drift time distributions as a function of activation voltage show that at low voltages selected structures undergo conformational transitions in what appears to be a pathway dependent fashion. Over a relatively wide range of intermediate activation voltages a distribution of states that is independent of the initial conformation selected for activation (as well as the activation voltage in this intermediate region) is established. This distribution appears to represent an equilibrium distribution of gas-phase structures that is reached prior to the energy required for dissociation. Establishment of a quasi-equilibrium prior to dissociation results in identical dissociation patterns for different selected conformations. A discussion of the transition from solution-like to gas-phase structures is provided.

Source: The Journal of Physical Chemistry B

DOI: 10.1021/jp102478k

Authors: Nicholas A. Pierson, Stephen J. Valentine, David E. Clemmer

Institutions: Indiana University Bloomington, Indiana University

Language: English

Topic: Mass Spectrometry Techniques and Applications

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Award: New Ion Mobility/Photodissociation Techniques for Analyzing Glycans