MeDALL (Mechanisms of the Development of ALLergy): an integrated approach from phenotypes to systems medicine
Year: 2011
Type: review
Study design: Study Protocol
Abstract: To cite this article: Bousquet J, Anto J, Auffray C, Akdis M, Cambon-Thomsen A, Keil T, Haahtela T, Lambrecht BN, Postma DS, Sunyer J, Valenta R, Akdis CA, Annesi-Maesano I, Arno A, Bachert C, Ballester F, Basagana X, Baumgartner U, Bindslev-Jensen C, Brunekreef B, Carlsen KH, Chatzi L, Crameri R, Eveno E, Forastiere F, Garcia-Aymerich J, Guerra S, Hammad H, Heinrich J, Hirsch D, Jacquemin B, Kauffmann F, Kerkhof M, Kogevinas M, Koppelman GH, Kowalski ML, Lau S, Lodrup-Carlsen KC, Lopez-Botet M, Lotvall J, Lupinek C, Maier D, Makela MJ, Martinez FD, Mestres J, Momas I, Nawijn MC, Neubauer A, Oddie S, Palkonen S, Pin I, Pison C, Rancé F, Reitamo S, Rial-Sebbag E, Salapatas M, Siroux V, Smagghe D, Torrent M, Toskala E, van Cauwenberge P, van Oosterhout AJM, Varraso R, von Hertzen L, Wickman M, Wijmenga C, Worm M, Wright J, Zuberbier T. MeDALL (Mechanisms of the Development of ALLergy): an integrated approach from phenotypes to systems medicine. Allergy 2011; 66: 596–604. The origin of the epidemic of IgE-associated (allergic) diseases is unclear. MeDALL (Mechanisms of the Development of ALLergy), an FP7 European Union project (No. 264357), aims to generate novel knowledge on the mechanisms of initiation of allergy and to propose early diagnosis, prevention, and targets for therapy. A novel phenotype definition and an integrative translational approach are needed to understand how a network of molecular and environmental factors can lead to complex allergic diseases. A novel, stepwise, large-scale, and integrative approach will be led by a network of complementary experts in allergy, epidemiology, allergen biochemistry, immunology, molecular biology, epigenetics, functional genomics, bioinformatics, computational and systems biology. The following steps are proposed: (i) Identification of ‘classical’ and ‘novel’ phenotypes in existing birth cohorts; (ii) Building discovery of the relevant mechanisms in IgE-associated allergic diseases in existing longitudinal birth cohorts and Karelian children; (iii) Validation and redefinition of classical and novel phenotypes of IgE-associated allergic diseases; and (iv) Translational integration of systems biology outcomes into health care, including societal aspects. MeDALL will lead to: (i) A better understanding of allergic phenotypes, thus expanding current knowledge of the genomic and environmental determinants of allergic diseases in an integrative way; (ii) Novel diagnostic tools for the early diagnosis of allergy, targets for the development of novel treatment modalities, and prevention of allergic diseases; (iii) Improving the health of European citizens as well as increasing the competitiveness and boosting the innovative capacity of Europe, while addressing global health issues and ethical issues.
Source: Allergy
Authors: J. Bousquet, J. Anto, C. Auffray, M. Akdis, A. Cambon-Thomsen, T. Keil, T. Haahtela, B. N. Lambrecht, D. S. Postma, J. Sunyer, R. Valenta, C. A. Akdis, I. Annesi-Maesano, A. Arno, C. Bachert, F. Ballester, X. Basagana, U. Baumgartner, C. Bindslev-Jensen, B. Brunekreef, K. H. Carlsen, L. Chatzi, R. Crameri, E. Eveno, F. Forastiere, J. Garcia-Aymerich, S. Guerra, H. Hammad, J. Heinrich, D. Hirsch, B. Jacquemin, F. Kauffmann, M. Kerkhof, M. Kogevinas, G. H. Koppelman, M. L. Kowalski, S. Lau, K. C. Lodrup-Carlsen, M. Lopez-Botet, J. Lotvall, C. Lupinek, D. Maier, M. J. Makela, F. D. Martinez, J. Mestres, I. Momas, M. C. Nawijn, A. Neubauer, S. Oddie, S. Palkonen, I. Pin, C. Pison, F. Rancé, S. Reitamo, E. Rial-Sebbag, M. Salapatas, V. Siroux, D. Smagghe, M. Torrent, E. Toskala, P. van Cauwenberge, A. J. M. van Oosterhout, R. Varraso, L. von Hertzen, M. Wickman, C. Wijmenga, M. Worm, J. Wright, T. Zuberbier
Institutions: Inserm, Centre de recherche en Epidémiologie et Santé des Populations, Hôpital Arnaud de Villeneuve, Universitat Pompeu Fabra, Center for Research in Environmental Epidemiology, Municipal Institute for Medical Research, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Hospital del Mar Research Institute, Centre National de la Recherche Scientifique, University of Zurich, Université Toulouse III - Paul Sabatier, Laboratoire Epidémiologie et Analyses en Santé Publique : Risques, Maladies Chroniques et Handicaps, Charité – Universitätsmedizin Berlin, Helsinki University Hospital, Ghent University Hospital, University Medical Center Groningen, University of Groningen, Medical University of Vienna, Université Pierre-et-Marie-Curie, Universitat de València, Centre for Public Health Research, Biomay (Austria), Odense University Hospital, Utrecht University, Oslo University Hospital, University of Oslo, University of Crete, Regione Lazio, University of Arizona, Helmholtz Munich, Inserm Transfert, Université Paris-Sud, National School of Public Health, Beatrix Kinderziekenhuis, Medical University of Lodz, Hospital Del Mar, University of Gothenburg, Biomax Informatics (Germany), Université Paris Descartes, Epidémiologie environnementale : impact sanitaire des pollutions, Bradford Royal Infirmary, Bradford Teaching Hospitals NHS Foundation Trust, Bradford Institute for Health Research, European Federation of Allergy and Airways Diseases Patients Associations, Université Joseph Fourier, Centre Hospitalier Universitaire de Grenoble, Institut pour l'avancée des biosciences, Hôpital des Enfants, Finnish Institute of Occupational Health, Ghent University, Karolinska Institutet, Sachs' Children and Youth Hospital
Language: English
Subfield: Immunology and Allergy
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funder: European Commission
OpenAlex ID: W2101860343