Work

Structural Examination of Supramolecular Architectures by Electrospray Ionization Mass Spectrometry

Year: 1999

Type: article

Abstract: Reversibly self-assembling host–guest complexes of the softball type are characterized by electrospray ionization mass spectrometry. Quaternary ammonium ions serve simultaneously as guests and ion labels. Isotope pattern analysis, inclusion of labeled guests, heterodimer experiments, size and shape dependence, and collision-induced fragmentation reveal that the capsular structure of these hydrogen-bonded complexes is retained in the gas phase with the guests inside their cavity. The results parallel findings from solution-phase NMR experiments and show that the guests are encapsulated inside the cavity. These results also demonstrate the value of mass spectrometry for high-order structural examination of supramolecular architecture.

Source: European Journal of Organic Chemistry

DOI: 10.1002/(sici)1099-0690(199906)1999:6<1325::aid-ejoc1325>3.0.co;2-6

Authors: Christoph A. Schalley, José M. Rivera, Tomás Martín, Javier Santamaría, Gary Siuzdak, Julius Rebek

Institution: Scripps Research Institute

Language: English

Topic: Mass Spectrometry Techniques and Applications

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: Foundation for the National Institutes of Health, Bundesministerium für Forschung und Technologie

OpenAlex ID: W2101871196

FWCI: 2.611

Cites: 70

Cited by: 46

Related to: 10