Work

T-Cell Vaccination Reduces Simian Immunodeficiency Virus Levels in Semen

Year: 2009

Type: article

Abstract: Recent findings suggest that most sexual transmission of human immunodeficiency virus type 1 (HIV-1) occurs during the acute phase of infection when viral replication is most intense. Here, we show that vaccine-elicited cellular immune responses can significantly reduce simian immunodeficiency virus levels in the semen during the period of primary infection in monkeys. A vaccine that decreases the quantity of HIV-1 in the semen of males during primary infection might decrease HIV-1 transmission in human populations and therefore affect the spread of AIDS.

Source: Journal of Virology

DOI: 10.1128/jvi.01202-09