Work

Involvement of Lysosomal Exocytosis in the Excretion of Mesoporous Silica Nanoparticles and Enhancement of the Drug Delivery Effect by Exocytosis Inhibition

Year: 2012

Type: article

Abstract: The exocytosis of phosphonate modified mesoporous silica nanoparticles (P-MSNs) is demonstrated and lysosomal exocytosis is identified as the mechanism responsible for this event. Regulation of P-MSN exocytosis can be achieved by inhibiting or accelerating lysosomal exocytosis. Slowing down P-MSN exocytosis enhances the drug delivery effect of CPT-loaded P-MSNs by improving cell killing.

Source: Small

DOI: 10.1002/smll.201201811

Authors: Rolando E. Yanes, Derrick Tarn, Angela A. Hwang, Daniel P. Ferris, Sean P. Sherman, Courtney R. Thomas, Jie Lu, April D. Pyle, Jeffrey I. Zink, Fuyuhiko Tamanoi

Institutions: California NanoSystems Institute, University of California, Los Angeles, UCLA Jonsson Comprehensive Cancer Center

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Cancer Institute, National Institute of General Medical Sciences

Awards: Nanovalve Platform: Targeted, Controlled, Release of Anticancer Drugs, Biotechnology Training in Biomedical Sciences and Engineering

OpenAlex ID: W2102046298

FWCI: 3.461

Cites: 60

Cited by: 167

Related to: 10