Evaluation of Acute Hematologic and Long-Term Pulmonary Toxicities of Radioimmunotherapy of Cryptococcus neoformans Infection in Murine Models
Year: 2004
Type: article
Abstract: We evaluated acute hematological and long-term pulmonary toxicity of radioimmunotherapy in murine models of Cryptococcus neoformans infection. Activities up to 250 microCi were well tolerated by healthy A/JCr mice for (213)Bi-18B7 and (188)Re-18B7 monoclonal antibodies. In infected mice, doses up to 150 microCi produced only transient toxicity. The lungs of treated mice had no evidence of radiation fibrosis.
Institutions: Cornell University, Albert Einstein College of Medicine
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2102108185