Year: 2015
Type: review
Abstract: Sensitization of the humoral immune response to invading viruses and production of antiviral antibodies forms part of the host antiviral repertoire. Paradoxically, for a number of viral pathogens, under certain conditions, antibodies provide an attractive means of enhanced virus entry and replication in a number of cell types. Known as antibody-dependent enhancement (ADE) of infection, the phenomenon occurs when virus-antibody immunocomplexes interact with cells bearing complement or Fc receptors, promoting internalization of the virus and increasing infection. Frequently associated with exacerbation of viral disease, ADE of infection presents a major obstacle to the prevention of viral disease by vaccination and is thought to be partly responsible for the adverse effects of novel antiviral therapeutics such as intravenous immunoglobulins. There is a growing body of work examining the intracellular signaling pathways and epitopes responsible for mediating ADE, with a view to aiding rational design of antiviral strategies. With in vitro studies also confirming ADE as a feature of infection for a growing number of viruses, challenges remain in understanding the multilayered molecular mechanisms of ADE and its effect on viral pathogenesis.
Source: Immunological Reviews
DOI: 10.1111/imr.12367
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
Awards: G1942825661, New insights into viral inflammatory disease mechanisms and approaches to therapy, How viruses cause arthritis, How chikungunya virus cause disease, A glycomics approach towards understanding alphavirus induced inflammatory disease and discovering novel therapeutic targets, Do Immigrating macrophages cause damage in the virus-infected brain?, Elucidating the mechanisms of how viruses cause arthritis, Immune modifying particles - a novel therapeutic strategy to treat lethal encephalitis, Integrated Chikungunya Research, G921956316
OpenAlex ID: W2102144534