Low frequency of cigarette smoking and the risk of head and neck cancer in the INHANCE consortium pooled analysis
Year: 2015
Type: article
Abstract: BACKGROUND: Cigarette smoking is a major risk factor for head and neck cancer (HNC). To our knowledge, low cigarette smoking (<10 cigarettes per day) has not been extensively investigated in fine categories or among never alcohol drinkers. METHODS: We conducted a pooled analysis of individual participant data from 23 independent case-control studies including 19 660 HNC cases and 25 566 controls. After exclusion of subjects using other tobacco products including cigars, pipes, snuffed or chewed tobacco and straw cigarettes (tobacco product used in Brazil), as well as subjects smoking more than 10 cigarettes per day, 4093 HNC cases and 13 416 controls were included in the analysis. The lifetime average frequency of cigarette consumption was categorized as follows: never cigarette users, >0-3, >3-5, >5-10 cigarettes per day. RESULTS: Smoking >0-3 cigarettes per day was associated with a 50% increased risk of HNC in the study population [odds ratio (OR) = 1.52, 95% confidence interval (CI): (1.21, 1.90). Smoking >3-5 cigarettes per day was associated in each subgroup from OR = 2.01 (95% CI: 1.22, 3.31) among never alcohol drinkers to OR = 2.74 (95% CI: 2.01, 3.74) among women and in each cancer site, particularly laryngeal cancer (OR = 3.48, 95% CI: 2.40, 5.05). However, the observed increased risk of HNC for low smoking frequency was not found among smokers with smoking duration shorter than 20 years. CONCLUSION: Our results suggest a public health message that low frequency of cigarette consumption contributes to the development of HNC. However, smoking duration seems to play at least an equal or a stronger role in the development of HNC.
DOI: 10.1093/ije/dyv146
Authors: Julien Berthiller, Kurt Straif, Antonio Agudo, Wolfgang Ahrens, Alexandre Bezerra dos Santos, Stefania Boccia, Gabriella Cadoni, Cristina Canova, Xavier Castellsague, Chu Chen, David Conway, Maria Paula Curado, Luigino Dal Maso, Alexander W Daudt, Eleonora Fabianova, Leticia Fernandez, Silvia Franceschi, Erica E Fukuyama, Richard B Hayes, Claire Healy, Rolando Herrero, Ivana Holcatova, Karl Kelsey, Kristina Kjaerheim, Sergio Koifman, Pagona Lagiou, Carlo La Vecchia, Philip Lazarus, Fabio Levi, Jolanta Lissowska, Tatiana Macfarlane, Dana Mates, Michael McClean, Ana Menezes, Franco Merletti, Hal Morgenstern, Joshua Muscat, Andrew F Olshan, Mark Purdue, Heribert Ramroth, Peter Rudnai, Stephen M Schwartz, Diego Serraino, Oxana Shangina, Elaine Smith, Erich M Sturgis, Neonila Szeszenia-Dabrowska, Peter Thomson, Thomas L Vaughan, Marta Vilensky, Qingyi Wei, Deborah M Winn, Victor Wünsch-Filho, Zuo-Feng Zhang, Ariana Znaor, Gilles Ferro, Paul Brennan, Paolo Boffetta, Mia Hashibe, Yuan-Chin Amy Lee
Institutions: Hospices Civils de Lyon, Centre international de recherche sur le cancer, Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Instituto do Câncer do Estado de São Paulo, Università Cattolica del Sacro Cuore, Istituti di Ricovero e Cura a Carattere Scientifico, University of Padua, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Fred Hutch Cancer Center, University of Glasgow, International Prevention Research Institute, Centro di Riferimento Oncologico, Hospital de Clínicas de Porto Alegre, Public Health Authority of the Slovak Republic, Instituto de Oncología y Radiobiología, New York University, Trinity College Dublin, Brown University, Cancer Registry of Norway, Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz, National and Kapodistrian University of Athens, Washington State University Spokane, Centre Hospitalier Universitaire Vaudois, Institute of Social and Preventive Medicine, The Maria Sklodowska-Curie National Research Institute of Oncology, University of Aberdeen, Institutul National de Sanatate Publica, Boston University, Universidade Federal de Pelotas, University of Turin, University of Michigan, U-M Rogel Cancer Center, Pennsylvania State University, University of North Carolina at Chapel Hill, National Institutes of Health, National Cancer Institute, Heidelberg University, Orszagos Kornyezetegeszsegugyi Intezet, Russian Cancer Research Center NN Blokhin, University of Iowa, The University of Texas MD Anderson Cancer Center, Nofer Institute of Occupational Medicine, Newcastle University, Universidad de Buenos Aires, Universidade de São Paulo, University of California, Los Angeles, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, University of Utah, Huntsman Cancer Institute
Language: English
Topic: Head and Neck Cancer Studies
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: World Health Organization, Memorial Sloan-Kettering Cancer Center, European Commission, Fundação de Amparo à Pesquisa do Estado de São Paulo, Associazione Italiana per la Ricerca sul Cancro, National Institute on Drug Abuse, National Cancer Institute, National Institute of Environmental Health Sciences, National Institute of Dental and Craniofacial Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: HELICOBACTER PYLORI MALNUTRITION AND GASTRIC CANCER, G1158119171, Molecular Epidemiology Cancer Training Program, G2432338990, Molecular Epidemiology of DNA Repair in Head and Neck Cancer, TOBACCO AND CANCER RISK--DOSE, METABOLISM AND GENETICS, Environmental, clinical, histopathological and molecular factors associated with development and prognosis of head and neck squamous cell carcinomas, G3708781070, Estudo internacional de fatores ambientais, vírus e câncer de cavidade oral e de laringe, The UGT2A and 3A metabolizing enzymes and tobacco-related cancer risk, ALCOHOL AND CANCERS OF THE LARYNX AND ESOPHAGUS, UCLA SPORE IN LUNG CANCER, GENETIC EPIDEMIOLOGY AND MECHANISMS IN ORAL CANCER, LUNG CANCER CHEMOPREVENTION WITH CELECOXIB IN EX-SMOKERS, G6063816319, ORAL CANCER--EPIDEMIOLOGY, BIOCHEMISTRY, &IMMUNOLOGY, G6446575152, Genetic Predictors for DNA Repair Phenotype in CMM, Epidemiology of protein glutathiolation, Carolina Population Center, Molecular Epidemiology and Gene-Environment Interaction, Patterns of Somatic Gene Alterations in Oral Cancer, G8101172206, International Head and Neck Cancer Consortium, MARIJUANA USE AND THE RISKS OF LUNG AND OTHER CANCERS, Pooled Analyses of SNPs and Risk of Head & Neck Cancer, The Boston Collaborative Oral Cancer Study, UDP-GLUCURONOSYLTRANSFERASE GENOTYPE AND CANCER RISK, UNC Center for Environmental Health and Susceptibility
OpenAlex ID: W2102163659