Craniofacial Tissue Engineering by Stem Cells
Year: 2006
Type: review
Abstract: Craniofacial tissue engineering promises the regeneration or de novo formation of dental, oral, and craniofacial structures lost to congenital anomalies, trauma, and diseases. Virtually all craniofacial structures are derivatives of mesenchymal cells. Mesenchymal stem cells are the offspring of mesenchymal cells following asymmetrical division, and reside in various craniofacial structures in the adult. Cells with characteristics of adult stem cells have been isolated from the dental pulp, the deciduous tooth, and the periodontium. Several craniofacial structures--such as the mandibular condyle, calvarial bone, cranial suture, and subcutaneous adipose tissue--have been engineered from mesenchymal stem cells, growth factor, and/or gene therapy approaches. As a departure from the reliance of current clinical practice on durable materials such as amalgam, composites, and metallic alloys, biological therapies utilize mesenchymal stem cells, delivered or internally recruited, to generate craniofacial structures in temporary scaffolding biomaterials. Craniofacial tissue engineering is likely to be realized in the foreseeable future, and represents an opportunity that dentistry cannot afford to miss.
Source: Journal of Dental Research
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: green
Awards: MORPHOGENESIS OF CRANIOFACIAL PRIMORDIA, G1719655710, G1721584166, G1816531886, MOLECULAR MECHANISMS OF CRANIAL SUTURE FUSION, G2836818435, CELLULAR AND MOLECULAR MECHANISMS OF CALVARIAL HEALING, G3250720597, MORPHOGENESIS AND PATTERNING OF CRANIOFACIAL PRIMORDIA, G3567893719, G4151940712, BONE MARROW STROMAL CELLS FOR SKELETAL REGENERATION, DISTRACTION OSTEOGENESIS--ENDOGENOUS TISSUE ENGINEERING, Dissecting Self-renewal Mechanisms of iPS Cells on Defined Synthetic Substrates, G4425714299, ENGINEERING CRANIOFACIAL OSTEOGENESIS--MECHANICAL FORCES, G5934578446, Stem Cell-Driven Regeneration of the Mandibular Joint, G6462177887, Periodontal Engineering Using Biomimetic Nano Scaffolds, Optimizing Mandibular Scaffold Modulus/Porosity Balance, Functional Tissue Engineering of Articular Condyle, Engineering Joint Scaffolds for Function/Regeneration, G7722678733, G784168553, G7864326885, Gene Therapy for Reconstructing Periodontal Tissues, Tissue Engineering and Regeneration, TNFR:Fc Gene Transfer for Treatment of Periodontitis, G933353739, Regeneration of Clinically Relevant Orofacial Tissues in Pre-Clinical Models
OpenAlex ID: W2102169821