Work

Remarkably High Rate of DNA Amplification Promoted by the Mating-Type Switching Mechanism in Schizosaccharomyces pombe

Year: 2012

Type: article

Abstract: A novel mating-type switching-defective mutant showed a highly unstable rearrangement at the mating-type locus (mat1) in fission yeast. The mutation resulted from local amplification of a 134-bp DNA fragment by the mat1-switching phenomenon. We speculate that the rolling-circle-like replication and homologous recombination might be the general mechanisms for local genome region expansion.

Source: Genetics

DOI: 10.1534/genetics.112.138727

Authors: Chuanhe Yu, Michael J Bonaduce, Amar J S Klar

Institutions: National Institutes of Health, National Cancer Institute

Language: English

Topic: Fungal and yeast genetics research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: National Institutes of Health, National Cancer Institute

OpenAlex ID: W2102178226