Work

LSH hamster model of syphilitic infection

Year: 1980

Type: article

Abstract: The inbred LSH/Se LAK strain of hamster can be infected with Treponema pallidum Bosnia A, the causative agent of endemic syphilis. When infected, this strain consistently produced extensive chronic skin lesions that persisted for 6 to 9 months, even in the presence of peak antitreponemal antibody titers. The lymph nodes increased in weight and contained measurable numbers of treponemes. This infection also gave the hamster cross-immunity to T. pallidum Nichols and Treponema pertenue, the causative agents of venereal syphilis and frambesia, respectively. LSH hamsters are thus an excellent model to study the immune response mechanisms to syphilitic infection.

Source: Infection and Immunity

DOI: 10.1128/iai.28.3.909-913.1980

Authors: R F Schell, J L LeFrock, J K Chan, O Bagasra

Institutions: Albany Medical College, Albany Medical Center Hospital

Language: English

Topic: Syphilis Diagnosis and Treatment

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: World Health Organization, National Institute of Allergy and Infectious Diseases