Work

Double dissociation of pharmacologically induced deficits in visual recognition and visual discrimination learning

Year: 2008

Type: preprint

Abstract: Monkeys trained in either one-trial recognition at 8- to 10-min delays or multi-trial discrimination habits with 24-h intertrial intervals received systemic cholinergic and dopaminergic antagonists, scopolamine and haloperidol, respectively, in separate sessions. Recognition memory was impaired markedly by scopolamine but not at all by haloperidol, whereas habit formation was impaired markedly by haloperidol but only minimally by scopolamine. These differential drug effects point to differences in synaptic modification induced by the two neuromodulators that parallel the contrasting properties of the two types of learning, namely, fast acquisition but weak retention of memories versus slow acquisition but durable retention of habits.

Source: Learning & Memory

DOI: 10.1101/lm.966208

Authors: Janita Turchi, Deanne Buffalari, Mortimer Mishkin

Institutions: National Institutes of Health, National Institute of Mental Health, Medical University of South Carolina

Language: English

Topic: Memory and Neural Mechanisms

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: U.S. Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health