Work

Effect of lung function and mode of inhalation on penetration of aerosol into the human lung.

Year: 1977

Type: article

Abstract: The method using radioactive tracer particles has been applied to study the effect of the mode of inhalation of aerosols on the depth of deposition in the lungs of 50 patients with airways obstruction. The findings show that the penetration of particles is directly related to: (1) volume inspired per breath (VI); (2) forced expiratory volume in one second (FEV1); and inversely related to (3) flow rate during inhalation (V). In mathematical terms, alveolar deposition (%) = 40-3 (VI)+10-98 (FEV1)--0-75 (V)+40-4; for this regression F = 4-41 and P less than 0-01.

Source: Thorax

DOI: 10.1136/thx.32.2.194

Authors: D Pavia, M L Thomson, S W Clarke, H S Shannon

Institutions: The Royal Free Hospital, London School of Hygiene & Tropical Medicine

Language: English

Topic: Inhalation and Respiratory Drug Delivery

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2102244429