Optimal sampling designs for accurate estimation of parasite clearance in the context of artemisinin resistance
Year: 2012
Type: article
Abstract: Background The emergence of artemisinin resistance in South East Asia threatens the efficacy of artemisinin derivatives (AD). Since the pharmacodynamic hallmark of AD is rapid parasite clearance, the clinical phenotype of slow clearance characterises resistance. This indicator remains critically important to monitor the extent of the problem in the absence of molecular marker(s) associated with artemisinin resistance and lack of sensitivity of current in vitro tests. Frequent parasite counts are needed to define clearance rate but it is uncertain what sampling frequency is required to ensure reliable estimates.
Source: Malaria Journal
Institutions: University of Oxford, Mahidol University, Shoklo Malaria Research Unit, Mahidol Oxford Tropical Medicine Research Unit, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Cambodia National Malaria Center, Kenya Medical Research Institute, KEMRI-Wellcome Trust Research Programme, Wellcome Trust, Karolinska University Hospital, Karolinska Institutet, Mahosot Hospital, Armed Forces Research Institute of Medical Science, Medical University of Vienna, University of Bamako, Malaria Research and Training Center
Language: English
Topic: Malaria Research and Control
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,890
OpenAlex ID: W2102387745