Carotid intima-media thickness in patients with chronic and aggressive periodontitis
Year: 2012
Type: article
Study design: Observational Study
Abstract: Objective: The objective of this study was to investigate the relationship between carotid intima-media thickness (IMT) and periodontal status in periodontitis patients. Materials and methods: The study was conducted on 128 subjects divided into four groups. The test groups consisted of 37 patients with chronic periodontitis (18 men and 19 women, mean age 57, 2±8, 0 years) and 30 patients with aggressive periodontitis (13 men and 17 women, mean age 34, 7±6, 3 years). There were 27 subjects in the control group for chronic periodontitis (11 men and 16 women, mean age 53, 0±10, 1 years), and 34 subjects in the control group for aggressive periodontitis (15 men and 19 women, mean age 27, 7±5, 7 years). Both control groups consisted of periodontally healthy volunteers. Periodontal condition was assessed using periodontal indices. Triglycerides, HDL cholesterol, LDL cholesterol, total serum cholesterol, high sensitive C-reactive protein (hsCRP), and glucose levels were quantified in serum. IMT measurements on common carotid artery were performed using Aloka ProSound ALPHA 10 with 13 MHz linear probe. Results: This research revealed significantly higher values of overall (0, 8 mm) and right (0, 8 mm) carotid IMT in chronic periodontitis patients only. Chronic periodontitis was statistically significant predictor (p=0, 003) for the right carotid IMT in the multivariate model, when potential confounding factors were included. Both periodontitis groups mainly included nonsmokers, and had statistically higher levels of hsCRP (2, 2 and 1, 4 mg/L). Conclusions: The study demonstrated that chronic periodontitis can be linked with carotid atherosclerosis, but further research is required to more precisely assess the influence of aggressive periodontitis on carotid IMT.
Source: Acta Stomatologica Croatica
Language: English
Subfield: Periodontics
Field: Dentistry
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2102511411