Year: 2015
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: To determine whether being pregnant in its own right alters epileptic seizure control. MATERIALS/METHODS: Study of 148 pregnancies in women who took no antiepileptic drugs before pregnancy and in at least the earlier half of pregnancy, 69 taking none throughout pregnancy. RESULTS: More women (P < 0.01) had seizures of any type during pregnancy (45.9%) than in the prepregnancy year (34.5%), and also convulsive seizures (30.4% vs 12.3%). After excluding potential confounding factors, viz. late prepregnancy drug withdrawal, treatment resumption in pregnancy possibly preventing seizure recurrence, the figures became seizures of any type 56.6% during and 35.5% before pregnancy and convulsive seizures 39.4% during and 18.2% before pregnancy (both P < 0.01). There was a non-statistically significant greater tendency for seizure control to be lost during pregnancy in genetic generalized than in focal epilepsies (54.2% vs 35.5%). CONCLUSIONS: Irrespective of its effects on antiepileptic drug disposition, being pregnant per se seems to impair epileptic seizure control.
Source: Acta Neurologica Scandinavica
DOI: 10.1111/ane.12479
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $2,490
OpenAlex ID: W2102533552