Work

A Simple and General Platform for Generating Stereochemically Complex Polyene Frameworks by Iterative Cross‐Coupling

Year: 2010

Type: article

Abstract: Not so complex: A novel iterative cross-coupling strategy provides access to useful building blocks that enable the simple preparation of complex polyene natural-product motifs in all possible stereoisomeric forms. The method was used to synthesize the polyene core of vacidin A (see structure).

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201004911

Authors: Suk Joong Lee, Thomas M. Anderson, Martin D. Burke

Institutions: Howard Hughes Medical Institute, University of Illinois Urbana-Champaign

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze