Work

Imaging Cell Death

Year: 2014

Type: article

Abstract: There is currently a need for imaging methods capable of detecting cell death in tissues and the early onset of tumor cell death resulting from therapy. However, to date, no probe has been approved for routine imaging of cell death in the clinic. The challenge is to identify hallmarks of cell death, which have clinical relevance, and then to develop and validate imaging biomarkers for these hallmarks. We focus here on cell death imaging probes, which either have been trialed in the clinic or have significant promise, based on preclinical studies.

Source: Journal of Nuclear Medicine

DOI: 10.2967/jnumed.112.114264

Authors: André A. Neves, Kevin M. Brindle

Institutions: Cancer Research UK Cambridge Center, University of Cambridge

Language: English

Topic: Cell death mechanisms and regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: Cancer Research UK